Of course!
The round ball was the first projectile; the conical bullet (I'm assuming you are talking about the Minie conical bullet), only lasted 40-50 years before it was replaced by breach loading weapons.
At first, straight rifling was cut into the bore of a muzzleloader as a way to prolong cleaning the fowling out of the bore between shots. It was found in the 14th or 15th century that imparting a spiral on the rifling of the bore on a round ball improved it's gyroscopic stability and accuracy.
Unlike in a conical, where the under-bore sized projectile must go through obturation, where the projectile gets squashed (the rear of the bullet begins moving before the front does, and it's "skirt" flares), thereby the bullet increases it's diameter so it fits into the rifling and provides a gas seal, a round ball is normally loaded enclosed in a lubricated patch of either cloth or leather. The patching provides at least three functions: 1. it mechanically cleans the bore as the round is shoved down into the breach of the rifle, and it's lube helps keep the residual fouling soft. 2. it takes up the "windage" between the diameter of the ball and the bore of the rifle so gas doesn't escape, 3. the lubed patch is what imparts the spin to the round ball.
If one is shooting a .36 caliber muzzleloader, the ball might be .35 caliber, and the patch would be at least .01 inch in thickness or thicker. One way to improve the accuracy of the round ball muzzleloader is to experiment with patch thickness to find what ball diameter/patch thickness the rifle likes.
If one is shooting a round ball out of a revolver, no patch is needed as the ball is nominally a little larger in caliber that the bore of the barrel, the forcing cone at the breach end of the barrel swages the ball down so it fits into the rifling.
Since a conical is longer (and heavier), than a round ball, the rifling inside the barrel must be of a faster twist in order to stabilize the projectile. A common twist rate for a round ball of .50 caliber might be one turn in 70 inches, whereas a .50 caliber conical might be one turn in 24 inches.