Probably. People think the uniforms and patriotic songs are great. That lasts until people are dying from dysentery and Confederates see gunboats that can outrange any artillery the Confederates had.
I watched a Yourube segment on the few Henry's rifles that were deployed by US soldiers. The Confederates quickly learned to identify the noise they made and avoid them.
The further speculation I would offer is that the US probably had to continue to war to complete victory after July 1863 to prevent an even greater demographic catastrophe. I think Grant observed during the war, that if the prisoner exchange protocols continued, the war would continue until every white man 18-35 years old in the south had become a casualty. Much worse outcomes were possible.
@Rhea Cole cites an example that occurred in South America.