I believe that threads on this subject only accentuate the fact that there was a fundamental disagreement on constitutional principles that existed between the different sections of the country. The argument over the rights of the states versus the power of the federal government was a source of controversy decades before the Civil War even began. Uncertainty as to what the federal government could and could not do began at the moment the Constitution was first adopted. This particular controversy was one of the reasons for the Civil War.
I agree, there were genuine philosophical differences that went back to the founders themselves. Hayne references Jefferson and Madison when he cites the Virginia and Kentucky resolutions.