After conducting many raids in Kansas, including the massacre at Lawrence, Quantrill decided to winter in Texas. Along with other partisans, he headed south on the Texas Road and captured and killed two Union teamsters who had come from a post called Baxter Springs. Quantrill decided to attack the post and divided his force into two columns, one under him and the other commanded by a subordinate, David Poole.

In a supposed retaliation for a Union raid on Osceola, Missouri, Lt. Col. William C. Quantrill led a force of about 300 to 400 partisans in an attack on the city of Lawrence, Kansas. His men killed civilians—men and boys—and destroyed many of the buildings.

Maj. Gen. Sterling Price led an expedition into Missouri which Union forces under Maj. Gen. Samuel R. Curtis and Maj. Gen. Alfred Pleasonton finally countered around Kansas City, Missouri. Price withdrew south, and Pleasonton, commanding in the field, pursued him into Kansas and fought him at Marais des Cygnes.

About six miles south of Trading Post, where the Marais de Cygnes engagement had occurred, the brigades of Col. Frederick W. Benteen and Col. John F. Phillips, of Maj. Gen. Alfred Pleasonton’s Provisional Cavalry Division, overtook the Confederates as they were crossing Mine Creek. These Rebels, stalled by their wagons crossing the ford, had formed a line on the north side of Mine Creek.